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At least she is looking forward ...

Image result for nobel peace prize 2019 

In about 10 min from now on the winner of the 100th Nobel Peace Prize will be announced live from Oslo, Norway.
Greta Thunberg, the 16-year-old climate activist, is widely considered by bookmakers to be the favorite to win the 100th Nobel Peace Prize. 

If she succeeds, she will become its youngest ever recipient -- a year younger than Malala Yousafzai was when she shared the award in 2014
To be honest, I find her character and personality highly disturbing.  Watching her speaches at the UN or at the climat summit, I had to turn down the sound. And also, I still believe that she has been used by others as a vehicle.
Image result for nobel peace prize 2019

But still, I believe that she should win the Peace Price or another highly recognized award.  And I also think that she should continue in her fight.  And I also think that her generation and also the elder ones (like me) should take her serious.  And this is why I think she is right:

Her anger about the slow political and economic changes away from the fossile energy sources is very rational, because it does not promote a move backward. She has no problems in promoting novel, innovative technologies. She even supported further usages of the (carbon saving) nuclear energy. 
She is not one of those eco-romantic who believe that we a life like in ancient times will be the future paradise. Greta is pro-technology, but she wants a faster usage of innovative technologies which are both make our lifes more convenient and the environment more clean. There are technologies like this, like the Maglev high-speed trains (abbandoned in Germany, but now re-developed in China), the HyperLoop (developed in California by Elon Musk) or synthetic, carbon neutral fuels (pioneered in Germany by Coren Technologies Inc.). 
The classical political greens, the organic and back-to-the-nature politicians, in contrast to Greta Thunberg, are sceptical about all modern technologies. And if they decide about our political agenda, we will really fall back and end in a deep recession.
In this sense, Mrs Thunberg is super-modern and super-realistic. And despite her strange character, she deserves the Nobel Peace Prize. Not least because Alfred Nobel himself demanded the prize winners to show a great dedication to human usage of technological innovations.

UPDATE:   11:12 pm, Greta Thunberg is not the winner, but the Ethiopian prime minister Abiy Ahmed for his effort to end the boarder conflict with Eritrea.  A could choise as well. And Greta will continue her climate campaign.


Germans and Austrians

Despite sharing a lot of its history with each other, vast cultural differences exist between Austrians and Germans. And a lot of them are reflected in a completely different meaning of certain words. A while ago, I received a written invitation from a local Tirolian-Austrian court, to report with them "to be executed". I replied that I have no intention and no time to be executed by them, due to private duties and an extraordinary big work load in our institute.
What was going on there at the Autrian court ?  Well, I had received a trafic ticket during a recent trip to Salzburg, and I failed to pay the fine. And when a sentence is administered in Austria, they call it "to execute". In Germany "to execute" means something like "to be put to death" (by hanging or electrich chair).

Another funny difference in using one and the same word is "Ausrasten".

Image result for wutThis is how it looks when a German "ausrasted":

 (like "going crazy",  "Ausrasten" lieterally means "to unlatch")

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And this is how it looks when an Austrian "ausrasted":

Here, "Ausrasten" is used in the sense of "having a good rest"


On the uselessness of prayers (Notre Dame burning down)

Since 5 hours now, a huge fire gormandizes its way through the Notre Dame cathedral in Paris. And with each more wing of the building the fire engulfes, the more it gets hungry for more food.

An unsatiable fire gorges through Notre Dame

And also since 5 hours, thousands, meanwhile millions of faithful people in Paris and all over the world are praying in public to make the fire stop. 

And these prayers are doing absolutely nothing.
What a sad occasion to think about the uselessness of religious faith. 
I deeply regret the loss of many masterpieces of human craftswork and creativity that where lost by this fire. But I have little sympathy for the millions of mourning catholics today. They neither expressed any sympathy for the thousands of "heretics" who were burned alife over the centuries.


Wrong models and fake models

Essentially, all models are wrong, but some of them are useful.
(George E.P. Box, statistician).
And all fashion models are fake, but none of them are useful.


A Good and a Bad Example

Already some years ago, after my own first episodes of writing a blog, I tried to understand what makes a good blog, and what makes a bad one. I finally came to the conclusion, that publicity is a bad measure. I have seen blogs of so unbelievable triviality (covering cosmetics, cooking, TV series, tourism), which attracted hundreds or even thousands of followers. And on the other hand, I read blogs that are of highest literature quality and of a philisophical depth that one often wishes they were available as hard copy in a bookstore. But usually, they attract only very few readers that follow and occasionally write a response. The weirdest example was a regular blog (on of the late Lars Gustafsson, the great cosmopolitan writer from Sweden, also philosopher and polymath, candidate for the Nobel prize, but ignored because his novels were too much fiction and psychology, and not politically explicit enough. Lars Gustafsson wrote his blog in English, and obviously he made little effort to increase in publicity, or pay for search engine optimization. I guess because of his fame in the international literature community, there must have been thousands of Google searches per day for his name, but obviously none of them found his privat blog. I think that including myself, there were lessless than 10 regular readers, obviously close friends of him, rather than book afficionados. Responses to his very long posts were rare, and I was perhaps the most frequent responder. So after a while, Gustafsson got used to start longer discussions with me, one of the readers of his blog whom he had never met in real life. During the 6 years that I followed his blog, his books were sold worldwide over several hundred thousand times, published in new translations, and awarded highest literature awards from different countries. But his personal blog remained a sort of secret jewel.
I neither did made much effort to change this, as one could have easily done by sending his blogs URL to literature critics, to his German publisher Hanser-Verlag, or posting it on Twitter. The last post Gustafsson wrote was in March 2016, about 3 weeks before his  death.
After this, nobody kept the blog alive, nobody wrote an orbituary. Since 3 years now, Lars Gustafssons blog is an orphan.
If I analyze the bloggers activities over the years (i.e. the frequency of posts that Gustafsson wrote per month), it is obvious that he enjoyed writing in this blogosphere, in an environment where he apparently felt less exposed to the literature world. From the year 2009 when he started his blog till the end in 2016, he used to write 2 - 3,  sometimes also 4 or 5 posts per month. This indicates that it was much more his personal satisfaction of being able to cover so many different topics in a none-curated manner on his blog, rather than a big audience, which motivated him to keep on writing there.

After my experience with a really exceptionally great blog - there are others, often by less famous writers - here is an examplean of how to write a bad blog.
A lady also writeswrites on for 6 years, but all in all only 12 posts. Sometimes, she stopped writing for half a year, but she always had about 60+ followers, and to each post between 5 and 10 responses that praised her cooking skills, wishing good luck with the house refurbishment, or confirming that spring time is the nicest season of the year. I guess that she made publicity for her blog among relatives and members of her church, since the responses all looked very superficially positive.
But if you sat down and carefully red a single of her texts, immediately you noticed the problem. Here is one from 2014:

"....Few months post wedding, I had to give up my job and we (I and my husband) had to move abroad for his job purposes.We moved to a beautiful city that happens to be one of the best places to live. We breathe the freshest possible air, watch the starry (and pollution-free) sky. It is an ideal place for anyone who wishes to live and grow up in a healthy environment...."

The blog author in this case seem to be afraid of telling too much from his private life to the unknown audience. She seem to believe that the ~60 followers who were personally invited to the blog knew her beforeway, so they knew what was her job, knew her husband, knew to which country and which beautiful city they moved. But to the anonymous reader on the internet, the text reads like answers of a witness at a criminal court: Don't reveal to much, only the facts, and stay as general as possible.
  • What was her job ?
  • What was the husbands name ?
  • To which country abroad they moved ?
  • Does this beautiful city also had a name, maybe it was as trivial as Rom, Paris, or Granada ?
  • Best place to live ?  By what measure, because it was clean as Singapure or cheap as Bazra  ?
  • Ideal place for anyone who loves healthy environment ? Whats about the millions of us who desperately wanting to live in an unhealthy environment (like Delhi, Karatchi or Marseille) ?
This is an example how a blog can become pretty boring, if the posts are kept in a very superficial style. The blog author does not seemed to feel much satisfaction from her blog neither, despite the regular response from buddy readers (in a facebook style of just doing someone a favour). In 2014, after receiving more praises and explicite encouragements to keep on writing (in response to a post about how to cook a shepperds pie and how to buy the ingredients as cheep as possible), the blog fell into silence. I first thought that maybe (like the sad experience with Gustafssons blog), some health issue or life changing event made it impossible for the author to carry on. But last year, i.e. after 4 years silence, a new post was written. This time it was about a trip to a nearby national park. Well, travelling can be at least as boring to write about as is cooking. So there is no danger if I un-follow this blog that I might miss anything exciting.


In a grey world, even the ordinary can look special

This is the original photography of a graffiti that I saw on a former army exercise area nearby. In contrast to the surrealistic impression this piece of artwork made in reality, I found it looked quite ordinary on a computer screen.
I therefore tried to change the background more to a spooky scenery.
When I changed the colours of the fields and trees to black&white, and only left the Graffiti in full colours, it became even more special.
The contrast effect was noted by the seventeenth century philosopher John Locke, who observed that lukewarm water can feel hot or cold, depending on whether the hand touching it was previously in hot or cold water. In the early twentieth century, Wilhelm Wundt identified contrast as a fundamental principle of perception, and since then the effect has been confirmed in many different areas. Contrast effects can shape not only visual qualities like color and brightness, but other kinds of perception, including the perception of weight. One experiment found that thinking of the name "Hitler" led to subjects rating a person as more friendly. Whether a piece of music is perceived as good or bad can depend on whether the music heard before it was unpleasant or pleasant.


Don't try to bluff a physicist in molecular biology

I remember this funny english book series, with the title "Bluff your way in ....", wherein "...." can be anything from history, philosophy to quantum mechanics or AI. As a physicist/biophysicist working in genetics and molecular biology research, I never felt the necessity to fake anything, though. Because both disciplines are very logical, complex and, (in case of genetics) even axiomatic. So quite suitable for a physicists brain to find enough challenges.
And I met many biologists and even medics who, on the other hand, feel a great attraction towards logic and quantitative thinking. But this week I had 2 really shoking encounters with colleagues, of whom one is even an institute director in molecular biology. Both have a PhD in biology, one is a full professor, the other a PI in cytogenetics. The cytogeneticist started to argue with me about the status of mammalian cell nucleus during mitosis (i.e. cell division, when the chromomes condense and become visible). The guy (who published many papers in cancer cytogenetics) was convinced that the chromosomes in metaphase are still confined within the nucleus. I told him that in metaphase there is no nucleus any more, because the nuclear envelop disappeares, and hence the condensed chromosomes are in the cytoplasm. He (at the age of 60 or so) had never heared about this.

In mammalian cells, chromosomes in metaphase are not confined in a nucleus any more, but entirely located in the cytpplasm.

And today I had a talk aside a thesis committee meeting with the mol.biol. professor. The guy really thought that mRNA splicing is happening in the cytoplasm, rather than in the nucleus. This is fundamentally so wrong, that it really made be jaw-dropping. Thats probably the whole difference between prokaryotes (nucleus-less bacteria) and eukaryotes (yeast, plants, animals, all of which have a nucleus in their cells). All organisms with a nucleus (eukaryotes) used to splice most of their messanger RNAs. Prokaryotes simply can not do this; their cells have not the necessary enzymes to do this complicate process. Therefore it is also logical that eukaryotic cells do mRNA splicing in their nuclei, and not in cytoplasm. 

Splicing of ncRNA into the mature mRNA is a process entirely in the nucleus. Only the spliced mRNA is exported to the cytoplasm (in order to be translated into proteins at the ribosomes)

For the mol.biol. professor (64 years old, 1 year before retirement), this was new information (hic!). One has to know that he is not only head of an institute, but also doing the exams for master- and doctoral-students (in molecular-biology, as one would easily guess).
So who has faked his entire professional career here ? Me, a self-trained geneticist with biophysic PhD, or them with their biology/molecular biology degrees ? I don't think that I am a nerd, such as the notorious Sheldon Lee Cooper, Ph.D., Sc.D from the freak show "Big Bang Theory". But at least I can put one and one together, and maybe in contrast to the biologists, who in part are still trained in the tradition of botanical encyclopedists, I always want to get a more comprehensive picture. And for me such a comprehensive picture of the processes in living organisms should be free of contradictions.
The two mechanisms described above, chromosomal segregation during metaphase and pre-mRNA splicing, are absolute essential processes that mark a cornerstone of higher evolution. Random chromosomal segregation outside of a nucleus not only happens in somatic cells a thousand of times every minute throughout our body, but it also takes place during meiosis in our reproductive organs (generation of sperms and oocytes). Sexual reproduction allows a much faster genetic drift as compared to asexual reproduction (clonal expansion), in which only genetic mutations could generate heritable variations in a phenotype. mRNA splicing is also a rather recent "invitation" by nature. Whereas the earliest know prokaryotic living cells (of the Archea domain) appeared on earth about 3.5 billion years ago, the first eukaryotes entered the stage of nature approximately 1.6–2.7 billion years ago (I can not remember the exact date sorry !!!). Splicing makes it possible to generate in multicellular organisms (metazoa) a huge variability of cell types, by differentially splicing the 35 thousand genes (estimation from the human genome) into at least 10 times more different mRNA species, which later can give rise to several hundred thousand different proteins. This makes the rather small genome of higher vertebrates (in comparison to protozoae fungi or even plants) so much more versatile. By fully exploiting the potential of differential splicing, higher vertebrates can much quicker respond to environmental challenges. Our immune system and our highly complex and adaptive brain makes heavy use of constantly changing the splicing pattern of some essential genes, thereby generating a lot of cellular plasticity.
I was shocked that the english Wikipedia does not mention mRNA splicing at all in the article on eukaryotes. Thats surprising, considering Wiki shall summarize the common knowledge of mankind.  Well, seems that again it needs a physicist to edit such a proto-type molecular biology entry. I promise in the next few days, I will add an extra chapter on the Wikipedia eukaryotes article and provide the link here on my blog post. Stay tuned, please.


Could you please give me a gentle kick-in-the-ass, s.v.p. ?!?!

I am quite good in advising others how to get things started, how to overcome procrastination. 

  • "Every long journey just starts with a first step forward"  
  •  If too many tasks pile up on your desk, prioritize them. Make a rank list with urgencies and importances of each task. Than start with the task that has the highest product of "Importance x Urgency"
  • Skip all the sweet little things that easily distract you and keep you busy the whole day long.   
Did I forgot something ? I am open for more good advises. Meanwhile, piles of papers and electronic files containing the results from several master and PhD projects from my lab are accumulating on my desk and on my computer. They would be sufficient to write at least 7 good papers for cancer biology and stem cell journals. 
I think I need someone who gives me a gentle kick-in-the-ass to start with the work. For the radiation-associated AML and Flt3 manuscript there is even a deadline by the International Journal of Molecular Science.
I should feel ashamed of letting them wait for too long time already.


Affirmative Action: Being torn between heart and reason

My reasoning brain tells me that affirmative action is something against nature. Because if nature would have allowed affirmative action, than the gazelle would have never developed into such a fast running and beautiful animal (intended to escape the predators), but evolution would have stalled at the stage of slow and lethargic goats. Instead, survival of the goats would have to be promoted by arbitrarily punishing a hunting cheetah with electric tasers, in order to fulfill a moral mission of supporting life of a creature in an unsuitable environment .
But one even does not has to go as far as to Darwinian evolution and survival of the fittest to find reasons against affirmative action:  Already on the submicroscopic level of macro molecular structure, the proper folding and hence functionality of proteins is governed by rewards and penalties which follow eternal, naturally given rules. Positively and negatively charged amino acids have a tendency of attraction, hydrophobic groups hide in the the center and hydrophilic groups are more exposed at the periphery of a protein. Affirmative action should encourage us (for the sake of justice) to equally allow also the hydrophobic amino acids to be exposed at the proteins periphery. Wouldn't it be morally wishful to give any amino acid - independent on its inherent properties- the chance to be "visible to the outer world" ? And indeed this would be possible, at least in a lab environment: Just heat up the proteins, and let them cool down slowly, and they will take any random configuration, with any of its amino acids having the same chance to pair with any other one, and equally likely being located on the outer surface or in the inner space.
Protein folding
By increasing the thermal energy (i.e. the temperature) the protein first unfolds to a more or less "anarchic" state. And when one reduces the temperature again, it will adopt all sorts of non-native meta-stable configurations (as shown by the local minima in the curve above), at which most of the amino acids occupy positions that are non-canonical but random. Here we might have an endless debate about what is canonical and what is not. Maybe one preferes one of the many metastable protein configurations much more than the native state. In fact you might like or dislike what you want, but fact is that the protein functions only in its native state. So whatever our moral subjectivity tries to tell us, there is only one configuration that works. And at this native configuration, all amino acids occupy their intended position. All the non-native states at which amino-acids are allowed to adopt non-canonical positions will in most cases lead to severe funtional impairment and diseases. In fact, some of the most devastating diseases - and some of the less treatable ones - are known today as being caused by protein misfolding. Alzheimer disease, Parkinson, Morbus Huntington, Cystic Fibrosis or other so-called proteopathies are of cause not the result of affirmative action by a benevolent human being, but of the detrimental interplay between genetic mutation, environmental factors and maybe a slow decline in  cellular check-up machinery. But the result is the same: The distortion of a native state and the formation of random and hence pathogenic states.
As a scientist, I therefore have big objections to a widespread use of affirmative action. I don't think it serves any good to promote - for good intention - a self-declared suppressed minority by discriminating the rest of the society. The human society is so diverse and complex that one can easily and arbitrarily define sub-groups ("tribes" to use a modern term), which by using questionable surveys can be shown to "suffer" from one or the other form of social discrimination.

Take for instance something very obvious: your home address. When we lived in London, our house was in the nice middleclass neighborhood of Battersea/Wandsworth. Our postal code was SW11 2AZ. A friend at work then asked me how it feels to live in such a wealthy borough.  Wealthy boroug ??? I asked him, after I had been involved in a fight with a drunken neighbor a few days before. It appeared that SW11 is in general considered to be of a good socio-economic background, and indeed just a few hundred meters away lived bankers, layers and folks from the media business. I was told that with my address and the SW11 postcode, I could easily apply for a well paid job in the financial industry. In the UK (and apparently other coutries like the US as well) your address postcode is used as a synonyme for your social status. On the other hand, of course, living at the "wrong" postcode (for instance Bethnal Green E2 6AU or Peckham SE15 5RJ) can be a really obstacle if you want to get a good job or intend to apply for a mortgage ("location, location, location, that's what counts"). When we believe in the beneficial effects of affirmative action, then we should turn this upside down and provide special quota of job positions or mortgages to be given to applicants from "dodgy postcodes".  With my SW11 postcode, I would have than been blocked from getting a good job or an affordable mortgage. But wait, our address in Battersea/Wandsworth was Jansen Walk 13, and isn't number 13 known to be considered also a bid scary ? Maybe I should have tried to promote myself as member of the discriminated tribe of No.13 residents. With some lobby work and some social media activities it should be possible to raise enough attention to fight for my (or OUR) case. At least in the case of getting a negative answer to a job application I could accuse the employer of discrimination because of my house number 13.

Jansen Walk
Janson Walk 13 in London SW11 2AZ: Excellent postcode, but suspicious house number.

Affirmative action is not such a big issue here in Germany, (except for womans quota) and maybe that was the reason that against my own judgement I recently followed my heart and not my mind. It happened at the refugee camp nearby, where I regularily help the school kids of the asylum seekers with their home work. And sometimes the parents of the kids also ask me for help with the language or with some beaurocratic issues. Nilab, a young mother from Afghanistan initially wanted me to help her with the language. She currently attends an integrative school to make her fit for a proper job training. For this, she already applies for apprenticeships as construction draftswoman. After a written application at a technical college she was asked to participate in an online test (obviously, the college forwared all applications to an assesment center).  Nilab was pretty nervous, considering that she is still not 100% familiar with the German language, and the online test requires a really quick understanding and answering.  So I agreed to "assist" her with the online test, which of course is against the rules. And "assisting" did not ment explaining her the question (which would have taken much to long), but I answered about 80% of the questions myself. I knew that this was not right, somehow in violation of my feeling that one should not positively discriminate a person to provide her with an advantage in a competitive situation.  I found the proper term for my doing, "Affirmative Action" only recently in the book "12 rules for life " by Jordan Peterson. Whereas in many points I can agree with his arguments, in the special situation of Nilab, a war refugee from Afghanistan, who is running her young family, living in a single studio of a refugee camp, learning a difficult new language, and above all is committed to learn a good and ambitious profession I saw no problem of promoting her against many obstacles of a western society.