Ghazal my Dear,
Do you think my french is o.k. for a week ? "Au Revoir", please tell me what it means. Is it like the german "Auf Wiedersehen" or like the english "Farewell" ? You probably know, cause you are the expert !
And of course I also like "Je ne regrette rien".
I doubt that the Cote de Azur will be as nice as the Isar-River banks with you in the Moon-Light.
TAKE CARE, my Dear
Michael
................................................................................................
hi michael,
yes, au revoir means Auf wiedersehen. hope you will have a great time there. and that the weather is good. good that you were able to save everything from your computer. even though 99% of it is useless. but it is good to save them maybe?
you still write on the blog? or just putting the emails there?
i want to continue with my thesis now. hope i will get something done.
yes i sometimes wonder, where my scientific carrier will lead.. how far will i get. and if i will continue as a scientist all my life..i hope so..but who knows.
take care
/ghazal
...............................................................................................
Ghazal my Dear,
we made a stop in Italy in a small town called San Giovanni.
Very tired. Hope you are o.k. and had a good day.
Have a quiet night and sleep well.
TAKE CARE
Michael
...............................................................................................
Hello Ghazal,
Hope you are doing well, hope everything is fine at work. I guess you are quite busy doing and analyzing the new sequences together with C.
I put two short chapters on Iodine and childhood thyroid cancer on your desk (Friday night,before I left). They are from the 2005 BEIR report (this is the commission on "Biological Effects of Ionizing Radiation" of the US National Research Council). Therefore, this is very condensed but high quality information. I am currently writing something for you about the synteny analysis of mouse and human genome (what I showed you last week, how the mouse loci correspond to the human ones for the FNMTC susceptibility).
Ghazal,my Dear, stay strong, send me something if you think I can help or contribute.
Michael
................................................................................................
Hi michael,
yes i miss my home, and famliy so so so much. cant believe i have been away for so long. yes when we do something fun then i forget about that for a while. but its not much left. i will be home soon.
its is sooo empty here. i havent seen c. and o. is sick so she is not here. so i could not get any RNA. i have started with the sequencing of the last gene (prop1). the other gene (gpx3) is already done, but we forgot to take it to the GAC. So I will hopefully take them both to GAC with claudia when she arrives this week.
The genotyping for the new-DNA is on the gel-electrophoresis. so if I get good pictures of it I should be done with the genotyping.
only remains the quantitative analysis (which I will wait to do next week when you are back right?)
and the qualitative which you already gave me the protocol for. But there is a question, why do I use the Balb/c and CBA embryo cDNA? shouldnt i use cDNA from the thyroid of JF1 and FVB?
then the writing. i have been writing. the part of genetic mapping, chi2-test and QTL, selection of the markers and the sensitivity of the mice that you wrote for me, should I change that? Or i can leave it as it is and find good references for them?
sorry for all the questions. but need to know..
soooo bad that its not nice there. i thought it is nice over there, near canne. well, its an experience as well. so try to have fun! so you cant reach the sea at all? no beach?
take care
/Ghazal
................................................................................................
hi michael,
he came at last, T. he wanted a print out of my thesis. but i said that its messy right now and so. so he just sat by the computer and we went through it. i think he liked it. but he told me to write about hyperthyroidism, and not only about cancer. he said a bit about marshall islands. that they really could not see any higher thyroid cancer among children because of the lack of time, that they were not allowed to continue. but they saw that children had higher risk. and there was a lot of radioiodine there.
anyway.. he asked about my project in sweden.. he did not seem interested. he said this project is better for me. genetics is better. but i want to go back and have good project. dont know why UV is not interesting.
well. have a good time.
and take care
/Ghazal
................................................................................................
Ghazal my Dear,
Thanks a lot for writing, it is good for me to read that you are doing well. It makes me the time away from Munich a little bit easier.
I attache a little bit text and a figure to explaine the concept of synteny analysis (relation between the mouse loci you found by QTL mapping and possible human loci that have to do with thyroid disease susceptibility).
Here the answers to your questions:
1: The qualitative analysis of the candidate gene trasncripts: ".....why do I use the Balb/c and CBA embryo cDNA? shouldnt i use cDNA from the thyroid of JF1 and FVB?"
Yes, of course, at the end you have to do the experiment on the FVB and JF1 thyroid cDNA. The embryo BALB and CBA was just to establish the assay (to check, of the two cDNA primers with the PCR conditions give the expected specific PCR product.
2: "....then the writing. i have been writing. the part of genetic mapping, chi2-test and QTL, selection of the markers and the sensitivity of the mice that you wrote for me, should I change that? Or i can leave it as it is and find good references for them? "
I would not take the text modules from me without any modifications. They should just give you an idea what should be the content and how much is neccessary. But I advice you to express it with your own words. It is much better for you also to learn and fully understand the stuff for the waiver in October.
Is it right that there is frost in germany ? Somebody from the hotel told me it is snowing. Unbelieveable, isn"t it. This makes me even more happy that always when we went out together in Munich, it was always nice and sunny (if the sun wasn"t shining, than the stars were out or the moon). I hope the september will be like this.
Ghazal, my Dear, I"ll write something in the evening, first wanted to send you the stuff for the thesis in case you are still at work.
TAKE CARE
Michael
................................................................................................
Hi Ghazal my Dear,
No, it is probably not right to say that it"s not nice hear. I"m just not in the mood at the moment to enjoy the Cote d"Azur.
The thing is, that how much one likes a city or a place depends so much on its personal situation. If one feels o.k. and happy,
than even the smallest hotel in the a dirty village might seem like heaven. And in contrast, if one does not feel comfortable, than even paradise island can be a nightmare.
In fact, I only came here to ensure my family some happy holidays, because my wife wished for a long time to visit her relatives and my son needs some relaxing days before school starts again.
For myself, however, it is not really relaxing. But as I said, it has mainly to do with me not wishing to leave munich right now, than with the place here.
The few details here that I criticised (the beach that can be reached only by passing a railway-line and a motorway or the heavy traffic around the hotel) are perhaps realy minor things. I usually would not notice them at all.
But in fact, I am comparing everything with the marvellous time you and me spend together sitting on the Isar river-side. This was for me like heaven on earth, like many other days I had the pleasure to discover with you some places in and around munich.
I recall these moments as if my eyes opened into a completely new world, or as if the world that I have known before was shining in a different light, maybe in a different wavelength as before, or just clearer and with more details.
I think I probably would have not noticed a single meteor this year if you would not have come to munich, because I usually forget the date in August. This year was completely different, I was waiting for the 12th of august impatiently, because I knew that perhaps it wont happen again (and perhaps has never happened to anybody before me) that you are waiting to spot "falling stars" in the company of an angel that has also fallen down from heaven to earth (just a couple of month earlier).
Ghazal, it might be that you laugh on me (and perhaps others who hear about this would also be very confused or amused), but I never thought before that at the end of the 4th decade of life I can be completely shaken up emotionally by a MSc student, who is in fact shy and calm and keeps a lot of mysteries hidden.
I hope I have not confused you too much, but as Edith Piaf has expressed it "Non, je ne regrette rien". But there is also the danger, that one never in life tries something risky and new and potentially revolutionary, if one always says "not doing anything I might later regrett". I am absolutely confident that I did right and will always do right trying to seduce you and to be more than just the supervisor. It could have been also very painful for me, you might have complaint at Prof. T. or at the personal department or at UCL about me, but I would not care about this. For me everthing was allright as it was and as it is, it was marvellous and it makes me happy.
Ghazal, my Dear, I hope you are relaxed these days, you sleep quiet and have nice dreams.
I miss you.
Take Care
Michael
................................................................................................
hi michael!!!
how are you?? try to enjooooy, i didnt want to make you feel like this. that you dont enjoy france and just want to come back to munich. what are you up to over there?
i would not complain to T. or anyone. i am enjoying my time here. and you have showed me alot of munich and helped me so much and made time and my project more fun.
im not happy right now! nothing seems to work in the lab:( this whole week i have tried and tried to do pcrs for different things. its just strange results. so i feel bad about it.. but will try again tomorrow.
i am going to london tomorrow night. when i come back my fathers wife will come and stay with me for a couple of days.
take care michael
................................................................................................
30.8.10
26.8.10
For Ghazal, the Scientist and for Ghazal, the Angel
Ghazal my Dear,
Are you still awake ? Do you have another conflict with some insects ?
I"ll drive by the guesthouse, and if there is still light behind your window, I call from downstairs. If not, I"ll go back.
M.
................................................................................................
Ghazal my Dear,
Have a good night, sleep well, dream about a journey to the moon, but my usuall plea: Please come back.
I like you so much, Ghazal for you stating "I don"t regret anything". If you are still awake, listen please to Edit Piaf.
TAKE CARE
Michael
................................................................................................
Are you still awake ? Do you have another conflict with some insects ?
I"ll drive by the guesthouse, and if there is still light behind your window, I call from downstairs. If not, I"ll go back.
M.
................................................................................................
Ghazal my Dear,
I wished we could stay there sitting and chatting untill the moon disappears in the morning. O.k., the following day in the lab would be a bit sleepy and dizzy,
but I would be happy. You see you experienced your first night out there in the wild, and no spiders, no bat no vampires or rapists. The world is sometimes much more comfortable and fazinating and lovely than our fears tell us.
Your hair has a tantalising smell. It was most difficult for me to tear away from it.but I would be happy. You see you experienced your first night out there in the wild, and no spiders, no bat no vampires or rapists. The world is sometimes much more comfortable and fazinating and lovely than our fears tell us.
Have a good night, sleep well, dream about a journey to the moon, but my usuall plea: Please come back.
I like you so much, Ghazal for you stating "I don"t regret anything". If you are still awake, listen please to Edit Piaf.
TAKE CARE
Michael
................................................................................................
Ghazal my Dear, now I try for the third time to write you a mail. Two hours ago, the Helmholtz mail server died, than I started to write the same mail on my privat mail-server, which suddenly also kicked me out and I lost 2 pages of text for you.Therefore, I now send you something short:I had this awfull job in the afternoon and evening to recover all personal date from my broken PC. These data were manuscripts, reports, science reviews, sequences, protocolls, gel-images, fotos of tumor and millions of other stuff I collected from my work during the last 12 years. And what I realized at the end: 99% of it is useless and wont be interesting for anybody any more. Isn"t this frustrating, how much we work what later got lost or what we later don"t want to read any more our self? In contrast to this, each time I read the text of the Persian-Cat blog, it makes me happy and excited and satisfied. As compared to all the million files on my computer disk, the blog is so small in size. But every word, every sentence is great, is relevant, as meaningful. And it will always be like this, I think not only you and me will always like to read this record of a wonderful summer and this funny exhange of thoughts between the two of us. I guess if other people read this, either now or 100 years later, they will also consider this great and important and simply human. Don"t worry, Ghazal, about what I wrote above regarding that work in science, and that it can sometimes appear useless to us. It is just a temporal feeling, and we all live in science for the very few moments when we make a great discovery and are Nobel-award candidates.You are still at the very beginning of your career, and I will do everything to encourage you to carry on. Because scientist can be one of the most satisfying and exciting jobs. But there always might be moments of frustration, and for these it is good if you have other areas of your soul that do not depend so much on how the gouvernment or the society or the boss or your colleagues judge your work, but a field that gives you power and satisfaction by itself. You have your beloved family, your movies and persian music, that will always help you to keep the head above. I "have" you, who just with a few words and a smile can compensate for a lot of hussle here at work (and of course I have other things, like music and books, that also help me to stay alive).What else shall I say?
Be strong, stay as lovely as you are, enjoy every day and every night and meet me at your deams.
Michael
Be strong, stay as lovely as you are, enjoy every day and every night and meet me at your deams.
22.8.10
Random Walk Model of two lovers
We were both on a random walk in time and space, since I saw you on the arms of your parents 21 years ago. The probability of a second encounter within the life-time of the universe would have been zero, thats for sure, but only if we assume that no attracting force exists between us..
These were the nights, my friend
Die Nächte sind das Thema, das uns nicht los lässt. Wir fabulieren über Schlafpositionen und Melatonin und Traumphasen und REM, wir treiben uns herum bis die Sperrstunde Dich ins Gästehaus zurück ruft. Wir versuchen, den Verlockungen und der Gefahr der Nacht davon zu laufen, in dem wir den Abschied möglichst weit hinaus schieben.
Der Abschied dann, in der halben Nacht ist immer ein Ringen, dann fürchten wir uns vor unseren eigenen Gefühlen und versuchen statt dessen, den Zweifeln des anderen zuvor zu kommen. Wir wissen doch, dass der anderen zweifelt, solange er den anderen für zweifelnd hält und so weiter und so weiter in einer endlosen Abfolge von gegenseitigen Gedankenspielen, die immer wieder auf sich selber bezogen sind so wie die Bilder in zwei sich gegenüber stehenden Spiegeln. Wir fürchten uns vor einer gemeinsamen Nacht, doch wir sehnen uns gleichzeitig nach dieser. Statt dessen beginnen wir jede Nacht eine Zwiesprache über e-mail, schicken uns Versicherungen dass wir an den anderen denken .
20.8.10
Champaign Dreams
I dreamed, that reason and truth might rule the world instead of religions and self-installed gods, and that the later are kept under glass in museums. And in my dreams there was no place any more for saints and gods, who use to judge man as heretics or as immoral.
I dreamed, that mankind will live free from hate against each other, that culture, birth, tradition, colour or race will loose its deviding function. I dreamed, that men find paradise here on earth, and not commiting crime and murder against each other to reserve a place in heaven after life. I dreamed, that love brings people together, rather that laws or social normatives, and that sympathy and attraction between two people would be the only reason to come together, not their cultural background, nor nation, gender or age.
I dreamed that people would do the biggest creations ever, not because they have to fight against poverty or death, but because they want to rise above nature and tradition and convention, because they want to discover the unknown land and conquere the desert and turn it into a flowering garden. I dreamed that men were doing good things, not because they fear punishment from a false god, but because they believe in the eternal values of good and beauty and truth.
I dreamed a silly dream, that at the end of my 4th life decade I start a second period of life with a 25 years old persian princess, who thinks that books and historical myths are useless, who fears spiders and ants, who loves McDonals and KFC fast food more than anything else. Whereas she does not know the magic of her blue eyes, she tries every morning to defeat her wild hair with cremes and razor-blades.
Ghazal, you should know that you are a woman, not a girl any more, and that you can easily drive a man into madness or into heroism. If you only want, you can be a queen and become myth as the founder of a new, enlightened empire, where love and reason rule, rather than superstition, religions and the hate and war they cause. Ghazal, my persian princess, your beauty and wisdom and grace does not put a spell only on me, but will seduce everybody who sees you.
...............................................................
Ich träumte, dass Vernuft die Welt regiert und Religionen nurmehr in Museen zu bestaunen seien und keine Götter uns mehr zu Ketzern oder zu Abtrünnigen abstempeln.
Ich träumte, dass Menschen ohne Hass leben, dass Herkunft, Kultur oder Tradition, Hautfarbe und Rassen unwichtig werden.Ich träumte, dass Menschen ihr Paradies hier auf Erden fänden, und nicht Verbrechen begehen müssten für ein jenseitiges Himmelreich. Ich träumte, dass Liebe die Menschen zusammenführte, und nicht staatliche Gesetze und Normen, dass Liebe das einzige Argument wäre für die Verbindung zwischen zwei Menschen, egal ob sie Geschlecht, Kultur, Nation oder Alter mehr trennt als vereint.
Ich träumte, dass die Menschen Grosses leisteten, ohne Angst vor der Armut, dass sie sich erheben über die Natur und über die Konventionen und über das Althergebrachte einzig und allein, weil sie nach Höherem und nach Wahrheit und nach Erkenntnis streben. Ich träumte, dass die Menschen gut sind weil sie an die Macht des Guten glauben, und nicht weil sie ein Gott belohnt oder bestraft für ihre irdischen Taten.
Ich träumte einen wahnsinnigen Traum, dass ich am Ende meines 4. Lebensjahrzents ein zweites Leben beginne mit einer 25-jährigen persischen Prinzessin, die mit Bücher und mit Historien-Mythen wenig anfangen kann, die sich vor Spinnen und Ameisen fürchtet, die Fast-Food von McDonalds und KFC vergöttert, die aber den Zauber ihrer blauen Augen selber noch nie wahr genommen hat und ihr widerspenstiges Haar mit Cremes und Rasiermessern zu bändigen versucht. Ghazal, Du bist eine Frau, Du bist kein Kind mehr, Du kannst einen Mann zum Wahnsinn treiben oder zum Heldentum, und wenn Du willst wirst Du zur Königin und zum Mythos eines aufgeklärten, neuen Reiches in dem Liebe und Vernuft regieren statt Aberglauben, Kirche und Hass.
Ghazal, meine persische Prinzessin, Deine Schönheit und Deine Anmut und Deine Klugheit schlägt nicht nur mich in seinen Bann, sondern wird alle verzaubern, die Dich erblicken.
I dreamed, that mankind will live free from hate against each other, that culture, birth, tradition, colour or race will loose its deviding function. I dreamed, that men find paradise here on earth, and not commiting crime and murder against each other to reserve a place in heaven after life. I dreamed, that love brings people together, rather that laws or social normatives, and that sympathy and attraction between two people would be the only reason to come together, not their cultural background, nor nation, gender or age.
I dreamed that people would do the biggest creations ever, not because they have to fight against poverty or death, but because they want to rise above nature and tradition and convention, because they want to discover the unknown land and conquere the desert and turn it into a flowering garden. I dreamed that men were doing good things, not because they fear punishment from a false god, but because they believe in the eternal values of good and beauty and truth.
I dreamed a silly dream, that at the end of my 4th life decade I start a second period of life with a 25 years old persian princess, who thinks that books and historical myths are useless, who fears spiders and ants, who loves McDonals and KFC fast food more than anything else. Whereas she does not know the magic of her blue eyes, she tries every morning to defeat her wild hair with cremes and razor-blades.
Ghazal, you should know that you are a woman, not a girl any more, and that you can easily drive a man into madness or into heroism. If you only want, you can be a queen and become myth as the founder of a new, enlightened empire, where love and reason rule, rather than superstition, religions and the hate and war they cause. Ghazal, my persian princess, your beauty and wisdom and grace does not put a spell only on me, but will seduce everybody who sees you.
...............................................................
Ich träumte, dass Vernuft die Welt regiert und Religionen nurmehr in Museen zu bestaunen seien und keine Götter uns mehr zu Ketzern oder zu Abtrünnigen abstempeln.
Ich träumte, dass Menschen ohne Hass leben, dass Herkunft, Kultur oder Tradition, Hautfarbe und Rassen unwichtig werden.Ich träumte, dass Menschen ihr Paradies hier auf Erden fänden, und nicht Verbrechen begehen müssten für ein jenseitiges Himmelreich. Ich träumte, dass Liebe die Menschen zusammenführte, und nicht staatliche Gesetze und Normen, dass Liebe das einzige Argument wäre für die Verbindung zwischen zwei Menschen, egal ob sie Geschlecht, Kultur, Nation oder Alter mehr trennt als vereint.
Ich träumte, dass die Menschen Grosses leisteten, ohne Angst vor der Armut, dass sie sich erheben über die Natur und über die Konventionen und über das Althergebrachte einzig und allein, weil sie nach Höherem und nach Wahrheit und nach Erkenntnis streben. Ich träumte, dass die Menschen gut sind weil sie an die Macht des Guten glauben, und nicht weil sie ein Gott belohnt oder bestraft für ihre irdischen Taten.
Ich träumte einen wahnsinnigen Traum, dass ich am Ende meines 4. Lebensjahrzents ein zweites Leben beginne mit einer 25-jährigen persischen Prinzessin, die mit Bücher und mit Historien-Mythen wenig anfangen kann, die sich vor Spinnen und Ameisen fürchtet, die Fast-Food von McDonalds und KFC vergöttert, die aber den Zauber ihrer blauen Augen selber noch nie wahr genommen hat und ihr widerspenstiges Haar mit Cremes und Rasiermessern zu bändigen versucht. Ghazal, Du bist eine Frau, Du bist kein Kind mehr, Du kannst einen Mann zum Wahnsinn treiben oder zum Heldentum, und wenn Du willst wirst Du zur Königin und zum Mythos eines aufgeklärten, neuen Reiches in dem Liebe und Vernuft regieren statt Aberglauben, Kirche und Hass.
Ghazal, meine persische Prinzessin, Deine Schönheit und Deine Anmut und Deine Klugheit schlägt nicht nur mich in seinen Bann, sondern wird alle verzaubern, die Dich erblicken.
18.8.10
Beach without you
Hi Ghazal, my Dear,
I hope you are doing well and feel o.k.
Is it quiet now in the Lab ? Usually this is the best time to concentrate on the project. I hope so much that you find some intellectual satisfaction with the project and not have to consider it as a hard burden and a duty to fulfill.
I prepared some text about the mapping, the markers, the mouse strains and linkage. It should somehow fit into the thesis structure (as much as I remember it was part 2 or so). Just break it apart into the several sub-headings.
And of course, if you find in the text something difficult to understand or wrong or strange, please write me back. I very much like the intellectual conversation with you and I learn a lot from your questions as well.
I will also send you something that explains the animal experiments (the older ones we did years ago and the JF1 x FVB crosses). Was Prof. T. already around ?
I think of you and your aristocratic character, that is so much different from the people here around which are very loud and miss any sense of ellegance. This is usually what one can expect at a beach,but the kids like this and therefore I have to decline.
I"m waiting to see you next week.
Take Care,my dear
Michael
................................................................
Hi Michael!!
T. has not been here yet. I think he chose this week on purpose. Both
you and M. are on vacation.
It is a bit quiet yes. I put aside the labwork yesterday and today to
sit and read and write. btw, the sequencing worked!! im happy. me and
claudia will maybe analyse the data later today.
it is not a burden to do this project. everything has been good so far.
I do not know how to thank you for writing so much for me. i have
written a bit about the mapping and microsatellite and QTL. but it was
not as much as yours. so thank you. you should not do this on your
vacation. just go and have fun. right now i am concentrating at the
first part with chernobyl and thyroid cancer.
take care and see you next week!
/ghazal
...............................................................
Ghazal my Dear,
Good to hear that you managed so well to continue with the project and the thesis during this week. Good luck with the sequence analysis,hope you and C. find some interesting variations between the two strains.
I attache a piece of text that describes the rational for using the JF1 and the FVB/N strain in this project. Please double-check if any of the chromosomal loci or gene names are consistent with what you wrote before. Also, in case you find any other discrepancies with the other text-pieces,please mark it in red and we will go through when I am back.
Ghazal, please don"t feel obliged to say "Thank you" for these small pieces of text. It is my very duty as a supervisor to help you with this. It is you who is doing the sophisticated and very decent experimental work day-by-day, without complaining that it is getting boring. Therefore,it is in fact me who must be extremely grateful. Don"t forget this, please.
And what is maybe even more relevant, that you always have this endless patience with me, if I come around and require that you spend the time after work with me. No MSc student has the commitment of going to the movies or to an exhibition or to the beach with its supervisor, or attend with him a concert or watch the meteor shower in the middle of the night. You could have in fact complaine with Prof. T. right from the beginning and ask for another project or another supervisor. I know I was always a bit violently when I asked you to meet me after work,and who knows how often I have disturbed your planing for the evening when you wanted to read or write something for the project. Therefore,it is the least I can do to help you to get everything together know for the thesis, it is a very small compensation for all the nice days and moments you have been with me and for having been always so patient and listened to my silly stories and telling me something from you. You could have easily send me to hell, you never did (I hope you dont wish you could have done this, but you did not wanted to risk your project).
Ghazal, you will see at the end (and everybody will agree) that a successful MSc project does not need this archetypical and hirarchical relation between student and supervisor, but it also can be done if there is a (sort of) frienship.
For me,to be honest, you are too much a mystery to call this a simple friendship.
I wish you a pleasant evening, a relaxing night, and nice dreams.
Michael
PS:How is your watch doing ? I hope that "No news are good news" and it runs precisely now, since you gave it a bit more freedom around your arm.
...............................................................
hi michael,
i think i found one mutation on the third exon.
yes u are right i could ask prof. t. for another project (and he would not give me another since i already tried in the beginning). but i enjoy it here i would not do it. u could also be a bad supervisor and not wanting to help. so i am grateful.
i send u a text with some questions. answer just if u have time. no hurry.
my watch is suprisingly doing great!its strange.
have a good day!!
/ghazal
................................................................
Ghazal my Dear,
Congratulations for finding a sequence variation in FGF10 in one of the mouse strains..
You could check (using Ensembl and search for FGF10 in mouse,and click on the left panel on the button for variations) if this sequence alteration was already described in any other mouse strain. You should also check if it might cause an amino-acid change, in case it is still part of the coding sequence (I remember large parts of exon 3 were already 3" UTR. Maybe you find something.
Before I left, I already ordered primers to test the FGF10 transcript and expression. Could you,please write a mail to O. and ask if and where she has stored the JF1 and FVB/N RNA or cDNA from thyroid (she extracted it as part of her MSc for the expression array).
Thanks for writing that you feel o.k. with how the project developed and that you are o.k. with everything and don"t regret that you came to Munich. You gave me the nicest and most exciting summer of my life, Ghazal. I never felt so much inspiration, excitement and satisfaction to share with somebody a project and many hours after work as with you.
Take Care
Michael
PS:I go through your text today and send you comments tomorrow
I hope you are doing well and feel o.k.
Is it quiet now in the Lab ? Usually this is the best time to concentrate on the project. I hope so much that you find some intellectual satisfaction with the project and not have to consider it as a hard burden and a duty to fulfill.
I prepared some text about the mapping, the markers, the mouse strains and linkage. It should somehow fit into the thesis structure (as much as I remember it was part 2 or so). Just break it apart into the several sub-headings.
And of course, if you find in the text something difficult to understand or wrong or strange, please write me back. I very much like the intellectual conversation with you and I learn a lot from your questions as well.
I will also send you something that explains the animal experiments (the older ones we did years ago and the JF1 x FVB crosses). Was Prof. T. already around ?
I think of you and your aristocratic character, that is so much different from the people here around which are very loud and miss any sense of ellegance. This is usually what one can expect at a beach,but the kids like this and therefore I have to decline.
I"m waiting to see you next week.
Take Care,my dear
Michael
................................................................
Hi Michael!!
T. has not been here yet. I think he chose this week on purpose. Both
you and M. are on vacation.
It is a bit quiet yes. I put aside the labwork yesterday and today to
sit and read and write. btw, the sequencing worked!! im happy. me and
claudia will maybe analyse the data later today.
it is not a burden to do this project. everything has been good so far.
I do not know how to thank you for writing so much for me. i have
written a bit about the mapping and microsatellite and QTL. but it was
not as much as yours. so thank you. you should not do this on your
vacation. just go and have fun. right now i am concentrating at the
first part with chernobyl and thyroid cancer.
take care and see you next week!
/ghazal
...............................................................
Ghazal my Dear,
Good to hear that you managed so well to continue with the project and the thesis during this week. Good luck with the sequence analysis,hope you and C. find some interesting variations between the two strains.
I attache a piece of text that describes the rational for using the JF1 and the FVB/N strain in this project. Please double-check if any of the chromosomal loci or gene names are consistent with what you wrote before. Also, in case you find any other discrepancies with the other text-pieces,please mark it in red and we will go through when I am back.
Ghazal, please don"t feel obliged to say "Thank you" for these small pieces of text. It is my very duty as a supervisor to help you with this. It is you who is doing the sophisticated and very decent experimental work day-by-day, without complaining that it is getting boring. Therefore,it is in fact me who must be extremely grateful. Don"t forget this, please.
And what is maybe even more relevant, that you always have this endless patience with me, if I come around and require that you spend the time after work with me. No MSc student has the commitment of going to the movies or to an exhibition or to the beach with its supervisor, or attend with him a concert or watch the meteor shower in the middle of the night. You could have in fact complaine with Prof. T. right from the beginning and ask for another project or another supervisor. I know I was always a bit violently when I asked you to meet me after work,and who knows how often I have disturbed your planing for the evening when you wanted to read or write something for the project. Therefore,it is the least I can do to help you to get everything together know for the thesis, it is a very small compensation for all the nice days and moments you have been with me and for having been always so patient and listened to my silly stories and telling me something from you. You could have easily send me to hell, you never did (I hope you dont wish you could have done this, but you did not wanted to risk your project).
Ghazal, you will see at the end (and everybody will agree) that a successful MSc project does not need this archetypical and hirarchical relation between student and supervisor, but it also can be done if there is a (sort of) frienship.
For me,to be honest, you are too much a mystery to call this a simple friendship.
I wish you a pleasant evening, a relaxing night, and nice dreams.
Michael
PS:How is your watch doing ? I hope that "No news are good news" and it runs precisely now, since you gave it a bit more freedom around your arm.
...............................................................
hi michael,
i think i found one mutation on the third exon.
yes u are right i could ask prof. t. for another project (and he would not give me another since i already tried in the beginning). but i enjoy it here i would not do it. u could also be a bad supervisor and not wanting to help. so i am grateful.
i send u a text with some questions. answer just if u have time. no hurry.
my watch is suprisingly doing great!its strange.
have a good day!!
/ghazal
................................................................
Ghazal my Dear,
Congratulations for finding a sequence variation in FGF10 in one of the mouse strains..
You could check (using Ensembl and search for FGF10 in mouse,and click on the left panel on the button for variations) if this sequence alteration was already described in any other mouse strain. You should also check if it might cause an amino-acid change, in case it is still part of the coding sequence (I remember large parts of exon 3 were already 3" UTR. Maybe you find something.
Before I left, I already ordered primers to test the FGF10 transcript and expression. Could you,please write a mail to O. and ask if and where she has stored the JF1 and FVB/N RNA or cDNA from thyroid (she extracted it as part of her MSc for the expression array).
Thanks for writing that you feel o.k. with how the project developed and that you are o.k. with everything and don"t regret that you came to Munich. You gave me the nicest and most exciting summer of my life, Ghazal. I never felt so much inspiration, excitement and satisfaction to share with somebody a project and many hours after work as with you.
Take Care
Michael
PS:I go through your text today and send you comments tomorrow
17.8.10
Breakfast at Tiffany"s
Ghazal my Dear,
It was funny to hear that your parents used the phrase "Breakfast at Tiffany"s" to express some special moments that they somehow did not wanted to further explaine to their kids. The movie "Breakfast at Tiffany"s" , probabaly much more than the original book by Truman Capote, really became a cult movie, although I have to admit I watched it only a few years ago for the first time (the book, like all others by Capote I used to read much earlier). I fully understand your parents keeping the movie in a special corner of their hearts, but It is a pitty they have never tried to introduce you to it and explained what is so special about it (but it is perhaps difficult to explain by words, you have to watch it yourself). I think its values and great humanity is absolutely timeless, people will always find it just wundereful, it is lovely and it is sad at the same time.
And Audrey Hepburn, who plays the main character Holly Golightly is still considered the most lovely face ever shown on a cinema screeen (if you read and believe the comments on the International Movie Database).
But here I have to intervene and insist, that another girl, one that fears spiders and loves fast-food at KFC, has eyes and a smile and a lovely voice that leaves me spellbound more than Audrey Hepburn.
There are a couple of nice scenes from the movie on youtube.
I wish you a good night, nice dreams, wild REM phases, and a relaxed morning.
Take Care, Don"t run away when I am not here.
Michael
PS: Do you remember the Svarovsky-Exhibition in Wattens/Austria I told you about. The glass cristals they produced somehow continue the craftsman tradition of Tiffany"s. This would be another reason to go their and watch the Galery.
................................................................
hi michael,
now i think you are on the way. hope u will have a nice time.
thank you for the video. it was nice.
i am going to helmholtz. i did not want to leave yesterday, i want to prepare more gel electrophoresis and then write a bit.
take care
/ghazal
................................................................
Hi Ghazal my Dear,
It is a quite wild place we ended here. Internet only accesible through a donkey path. Have a nice Sunday.
Is it as hot in Germany as it is here ?
Did you had a nice weekend ? Breakfast at Tiffany"s is rarely on the cinema program. We have to wait or I"ll try to get a DVD.
Relax. my dear
Michael
.............................................................
hi michael,
it was sunny, but not so warm, not inside anyway. yes i went to helmholtz yesterday, all alone. scary. did some pcr and elecrophoresis. and wrote a bit. today i tried to write a bit more. i looked at the cd you gave me, alot of articles there! got a bit scared, but its good.
have a nice and relaxing time there.
take care.
/Ghazal
................................................................
Ghazal, my dear,
thank you so much for writing occasionally. It warms up my heart (might sound very romantic, but it is real).
I hope you are o.k. I hope it was not too scary in the institute during the weekend. Did you came by bike ?
I don"t really feel here as I am doing vacacions. My thoughts are too much in munich, I"m worrying that you might need me right now to prepare the text for Prof. T. and to plan the next experiments.
Please, don"t hesitate to send me some parts of the text to go through. I really have nothing else important to do here.
I read some books here, but they can wait. For me it would be a pleasure to help you to take off some of the pressure.
Take Care, my dear
Michael
PS: The sea here is pretty wild. The beach is virtually made from rocks, and we are all a bit injured already. I hope there is sufficient Iodine in the sea water
to keep my wounds free of infections. You see, even here 900 km away from munich the iodine stays in the center of attention.
It was funny to hear that your parents used the phrase "Breakfast at Tiffany"s" to express some special moments that they somehow did not wanted to further explaine to their kids. The movie "Breakfast at Tiffany"s" , probabaly much more than the original book by Truman Capote, really became a cult movie, although I have to admit I watched it only a few years ago for the first time (the book, like all others by Capote I used to read much earlier). I fully understand your parents keeping the movie in a special corner of their hearts, but It is a pitty they have never tried to introduce you to it and explained what is so special about it (but it is perhaps difficult to explain by words, you have to watch it yourself). I think its values and great humanity is absolutely timeless, people will always find it just wundereful, it is lovely and it is sad at the same time.
And Audrey Hepburn, who plays the main character Holly Golightly is still considered the most lovely face ever shown on a cinema screeen (if you read and believe the comments on the International Movie Database).
But here I have to intervene and insist, that another girl, one that fears spiders and loves fast-food at KFC, has eyes and a smile and a lovely voice that leaves me spellbound more than Audrey Hepburn.
There are a couple of nice scenes from the movie on youtube.
I wish you a good night, nice dreams, wild REM phases, and a relaxed morning.
Take Care, Don"t run away when I am not here.
Michael
PS: Do you remember the Svarovsky-Exhibition in Wattens/Austria I told you about. The glass cristals they produced somehow continue the craftsman tradition of Tiffany"s. This would be another reason to go their and watch the Galery.
................................................................
hi michael,
now i think you are on the way. hope u will have a nice time.
thank you for the video. it was nice.
i am going to helmholtz. i did not want to leave yesterday, i want to prepare more gel electrophoresis and then write a bit.
take care
/ghazal
................................................................
Hi Ghazal my Dear,
It is a quite wild place we ended here. Internet only accesible through a donkey path. Have a nice Sunday.
Is it as hot in Germany as it is here ?
Did you had a nice weekend ? Breakfast at Tiffany"s is rarely on the cinema program. We have to wait or I"ll try to get a DVD.
Relax. my dear
Michael
.............................................................
hi michael,
it was sunny, but not so warm, not inside anyway. yes i went to helmholtz yesterday, all alone. scary. did some pcr and elecrophoresis. and wrote a bit. today i tried to write a bit more. i looked at the cd you gave me, alot of articles there! got a bit scared, but its good.
have a nice and relaxing time there.
take care.
/Ghazal
................................................................
Ghazal, my dear,
thank you so much for writing occasionally. It warms up my heart (might sound very romantic, but it is real).
I hope you are o.k. I hope it was not too scary in the institute during the weekend. Did you came by bike ?
I don"t really feel here as I am doing vacacions. My thoughts are too much in munich, I"m worrying that you might need me right now to prepare the text for Prof. T. and to plan the next experiments.
Please, don"t hesitate to send me some parts of the text to go through. I really have nothing else important to do here.
I read some books here, but they can wait. For me it would be a pleasure to help you to take off some of the pressure.
Take Care, my dear
Michael
PS: The sea here is pretty wild. The beach is virtually made from rocks, and we are all a bit injured already. I hope there is sufficient Iodine in the sea water
to keep my wounds free of infections. You see, even here 900 km away from munich the iodine stays in the center of attention.
11.8.10
Spot the Stjaernfallen next week
Hi Ghazal my Dear,
Don"t know were you spend the evening tonight, but I"d like to remind you of the Perseiden Stjaernfallen that are most prominent these days. I think to watch them is also a good remedy for the sadness that one usually gets before beloved people leave.
Since the next two days might be quite cloudy, I think tonight is the only chance to view the fallen stars (nice term, isn"t it. Maybe we can see fallen stars like Whitney Houston, Britney Spears or Mikey Rourke tonight, or Michael Schumacher, Maradonna and the like).
To be honest, real Stjaernfallen are much nicer than these celebrities that greet us every day from the yellow-press.
To help you find the Perseides and have a good chance to spot some of the meteors, I made a scheme for you to get an orientation on the night sky.
First try to find the northern direction (from your house look towards the Olympia TV-tower). Then turn your head further to the right, untill you see somewhere a very prominent constellation of stars called Cassiopeia (like a hughe W on the sky). Below or slightly left of Cassiopeia (depending at what time at night you are there) there is the constellation called Perseus, and the Stjaernfallen should originate from this site.
As I told you, according to mythology, you can express a wish whenever you see a Stjaernfallen, but you should not tell anybody about it.
I saw some already yesterday night, and I hope that neither of my wishes collided with your future planing. I tried to avoid anything that is related to the place or the country where you want to do your PhD project (I think this question is too much conflict-loaded).
Therefore, I"ll continue with wishes that I think everybody can live with.
Would be nice to read some words from you
Take Care
Michael
PS:
Just to avoid any confusion on the night sky: the description above referes to the site of I.s house. In case you are in Unterschleissheim tonight, you have to look north, but this will be almost opposite to the Olympia-TV-Tower. Standing in front of the guesthouse, you should then turn your eyes to the left (along Edith-Stein-Strasse).
Maybe you are not in the mood to watch the stars tonight at all. But be careful, than all my (crazy) wishes might come true.
Take Care, my dear
Michael
Don"t know were you spend the evening tonight, but I"d like to remind you of the Perseiden Stjaernfallen that are most prominent these days. I think to watch them is also a good remedy for the sadness that one usually gets before beloved people leave.
Since the next two days might be quite cloudy, I think tonight is the only chance to view the fallen stars (nice term, isn"t it. Maybe we can see fallen stars like Whitney Houston, Britney Spears or Mikey Rourke tonight, or Michael Schumacher, Maradonna and the like).
To be honest, real Stjaernfallen are much nicer than these celebrities that greet us every day from the yellow-press.
To help you find the Perseides and have a good chance to spot some of the meteors, I made a scheme for you to get an orientation on the night sky.
First try to find the northern direction (from your house look towards the Olympia TV-tower). Then turn your head further to the right, untill you see somewhere a very prominent constellation of stars called Cassiopeia (like a hughe W on the sky). Below or slightly left of Cassiopeia (depending at what time at night you are there) there is the constellation called Perseus, and the Stjaernfallen should originate from this site.
As I told you, according to mythology, you can express a wish whenever you see a Stjaernfallen, but you should not tell anybody about it.
I saw some already yesterday night, and I hope that neither of my wishes collided with your future planing. I tried to avoid anything that is related to the place or the country where you want to do your PhD project (I think this question is too much conflict-loaded).
Therefore, I"ll continue with wishes that I think everybody can live with.
Would be nice to read some words from you
Take Care
Michael
PS:
Just to avoid any confusion on the night sky: the description above referes to the site of I.s house. In case you are in Unterschleissheim tonight, you have to look north, but this will be almost opposite to the Olympia-TV-Tower. Standing in front of the guesthouse, you should then turn your eyes to the left (along Edith-Stein-Strasse).
Maybe you are not in the mood to watch the stars tonight at all. But be careful, than all my (crazy) wishes might come true.
Take Care, my dear
Michael
10.8.10
What a great song
Dear Ghazal,
Sorry for bothering you once again. Its not nice, I know, I"m sure you want to spend the last evening with your family without beeing disturbed by this silly guy from the institute.
So you don" t have to read this, maybe just keep it for later.
I was listening to the radio-station that you have shown me recently when we were coming back from the lake (Radio2Day). I have to admit, it is really the station with the nicest program. I only can not imagine, how you got caught by it, since they play only music from 20 years ago or so. It would confirm my suggestion that one instinctively likes the music that was around when one was still in the embryonal state or just born.
One of the greatest song ever sung they were just playing now, Gloria Gaynors "I will survive". It is such an amazing and strong song, I could imagine that you sing it once. I hope that you will always be as strong as Gloria Gaynor and that you will never give up.
B.t.w. the whole Radio2Days you can listen through web-stream.
Sorry for beeing so unpersonal, Ghazal, but I haven"t heard from you something since Sunday, so I can not reply really to something that you wrote. I just like balloon flying with the wind here and there, and picking up what is around.
I miss you, there is nobody taking care of me
Michael
Sorry for bothering you once again. Its not nice, I know, I"m sure you want to spend the last evening with your family without beeing disturbed by this silly guy from the institute.
So you don" t have to read this, maybe just keep it for later.
I was listening to the radio-station that you have shown me recently when we were coming back from the lake (Radio2Day). I have to admit, it is really the station with the nicest program. I only can not imagine, how you got caught by it, since they play only music from 20 years ago or so. It would confirm my suggestion that one instinctively likes the music that was around when one was still in the embryonal state or just born.
One of the greatest song ever sung they were just playing now, Gloria Gaynors "I will survive". It is such an amazing and strong song, I could imagine that you sing it once. I hope that you will always be as strong as Gloria Gaynor and that you will never give up.
B.t.w. the whole Radio2Days you can listen through web-stream.
Sorry for beeing so unpersonal, Ghazal, but I haven"t heard from you something since Sunday, so I can not reply really to something that you wrote. I just like balloon flying with the wind here and there, and picking up what is around.
I miss you, there is nobody taking care of me
Michael
There are more things in heaven and earth, Horatio,Than are dreamt of in our philosophy ++++ (Hamlet)
Hi Ghazal, my Dear,
Don"t know why I used the above "Subject" for this e-mail, but I guess Shakespeare fits equally well for many different occasions.
We gave B. today another 72 (!!!) tailtips to extract DNA from, to be used for fine-mapping. But as we discussed last week, you only have to genotype for the two flanking markers. Then it is enough to continue with the few (I estimate between 10 and 15) which have cross-over in this intervall, and use only for those the additional markers in between.
Don"t know why I"m so technical, guess you find this not very friendly. I should rather ask how you are doing, but I guess this is self-explained.
Ghazal you know, when you are away for a longer time I"m always worried that you wont come back at all. Therefore I so much depend on you sending some words or thoughts in the evening.
Hope we see you soon back.
Today I. wrote that she changed her flight, will only arrive on Wednesday. So you can carry on with the "Kuddkrig" and with "Bed-Jumping" (Please make a video of this, we can later upload it to Youtube and send a link to I :-)
Sleep well, dream well, relax
Michael
Don"t know why I used the above "Subject" for this e-mail, but I guess Shakespeare fits equally well for many different occasions.
We gave B. today another 72 (!!!) tailtips to extract DNA from, to be used for fine-mapping. But as we discussed last week, you only have to genotype for the two flanking markers. Then it is enough to continue with the few (I estimate between 10 and 15) which have cross-over in this intervall, and use only for those the additional markers in between.
Don"t know why I"m so technical, guess you find this not very friendly. I should rather ask how you are doing, but I guess this is self-explained.
Ghazal you know, when you are away for a longer time I"m always worried that you wont come back at all. Therefore I so much depend on you sending some words or thoughts in the evening.
Hope we see you soon back.
Today I. wrote that she changed her flight, will only arrive on Wednesday. So you can carry on with the "Kuddkrig" and with "Bed-Jumping" (Please make a video of this, we can later upload it to Youtube and send a link to I :-)
Sleep well, dream well, relax
Michael
7.8.10
Quantum Entanglement, Dogs and the Problem of Longitude
Hi Ghazal, my Dear,
Hope you didn" got lost on your Random Walk (swedish "Slump Promenade") through the Olympia shopping mall.
The swedish "Slump" (for Randomness) is really a very, very strange word, isn"t it. And in research, randomness is always what we like to minimize because it tends to obscure our observations, which we would like so much to interprete as a result of shear causality. In the formular for the genetic LOD-score = log10 (Likelihood for Linkage by causative gene)/(Likelihood for Linkage by chance) it is the denominator standing below the fraction line.
Interesting, in the swedish Wikipedia-entry for Slump/Randomness there is a indirect link to a subject I already mentioned recently: Quantum Entanglement or Kvantmekanisk sammanflätning. This subject is still a hot issue between opponents and proponets of the quantum-mechanics. But there is good evidence that it works. The principle is as following: You take two particles that form a pair (having a joint wavefunction) and therefore are dependent from each other in their quantum-mechanical status. When you separate them spatially, their joint wavefunction remains and therefore their correlation is preserved. It is now believed, that by "taking on of these particles with you" wherever you go, and leave the other particle at home, you always can determine the status of the remote particle. A recent study published in NATURE estimated, that the speed by which information can be exchanged this way is about 10 000 times faster than speed of light.
My proposal, you remember, was to use our two twin DKNY watches for a permanent informational link between us, because their status I believe is already "entangled" .
A funny idea emerged in the 18th century, assuming an extra-sensual information transfer could solve the problem in sea navigations of how to keep the precise time from their home country (this was crucial to determine the longitude). There was the hilarious theory that if you take two dogs from the same litter (virtually twins), and you leave one of them at home and take the other one on board a ship that will go around the world, then the two dogs remain linked to each other by a transzendental and telepathic connection. Therefore, whenever the dog at home is hurt (for instance by peeking it with a needle), the other dog on-board the ship instantly feels the pain and howls loudely. So when the dog that is left home is hurt once a day at 12 o"clock midday, the people on board the ship hear the second dog howling and this way they know precisely when it is 12 o"clock at home. Funny idea, isn"t it.
Unfortunately (but maybe furtunately for the dogs) this project never worked ;-}, and finally the english carpenter and self-educated watchmaker John Harrison constructed in the year 1735 the first ship chronometer that run precise enough over many weeks on board the ship and therefore allowed the determination of the geographic longitude.
Although the strange idea to use dogs telepathic abilities for this purpose was born in England in the 18th century, it later appeared so hilarious that nowadays the english Wikipedia refers to it only in an entry on "Powder of Sympathy" rather than in its larger article on "The problem of Longitude". The german, as always very open to strange and esoteric ideas, still reproduces this telepathic dog hypothesis in their Wikipedia.
But who knows, maybe today with the knowledge of quantum-mechanic entanglement we can make it work using our two watches.
Enjoy the time, my dear, don"t condemn me
Michael
Hope you didn" got lost on your Random Walk (swedish "Slump Promenade") through the Olympia shopping mall.
The swedish "Slump" (for Randomness) is really a very, very strange word, isn"t it. And in research, randomness is always what we like to minimize because it tends to obscure our observations, which we would like so much to interprete as a result of shear causality. In the formular for the genetic LOD-score = log10 (Likelihood for Linkage by causative gene)/(Likelihood for Linkage by chance) it is the denominator standing below the fraction line.
Interesting, in the swedish Wikipedia-entry for Slump/Randomness there is a indirect link to a subject I already mentioned recently: Quantum Entanglement or Kvantmekanisk sammanflätning. This subject is still a hot issue between opponents and proponets of the quantum-mechanics. But there is good evidence that it works. The principle is as following: You take two particles that form a pair (having a joint wavefunction) and therefore are dependent from each other in their quantum-mechanical status. When you separate them spatially, their joint wavefunction remains and therefore their correlation is preserved. It is now believed, that by "taking on of these particles with you" wherever you go, and leave the other particle at home, you always can determine the status of the remote particle. A recent study published in NATURE estimated, that the speed by which information can be exchanged this way is about 10 000 times faster than speed of light.
My proposal, you remember, was to use our two twin DKNY watches for a permanent informational link between us, because their status I believe is already "entangled" .
A funny idea emerged in the 18th century, assuming an extra-sensual information transfer could solve the problem in sea navigations of how to keep the precise time from their home country (this was crucial to determine the longitude). There was the hilarious theory that if you take two dogs from the same litter (virtually twins), and you leave one of them at home and take the other one on board a ship that will go around the world, then the two dogs remain linked to each other by a transzendental and telepathic connection. Therefore, whenever the dog at home is hurt (for instance by peeking it with a needle), the other dog on-board the ship instantly feels the pain and howls loudely. So when the dog that is left home is hurt once a day at 12 o"clock midday, the people on board the ship hear the second dog howling and this way they know precisely when it is 12 o"clock at home. Funny idea, isn"t it.
Unfortunately (but maybe furtunately for the dogs) this project never worked ;-}, and finally the english carpenter and self-educated watchmaker John Harrison constructed in the year 1735 the first ship chronometer that run precise enough over many weeks on board the ship and therefore allowed the determination of the geographic longitude.
Although the strange idea to use dogs telepathic abilities for this purpose was born in England in the 18th century, it later appeared so hilarious that nowadays the english Wikipedia refers to it only in an entry on "Powder of Sympathy" rather than in its larger article on "The problem of Longitude". The german, as always very open to strange and esoteric ideas, still reproduces this telepathic dog hypothesis in their Wikipedia.
But who knows, maybe today with the knowledge of quantum-mechanic entanglement we can make it work using our two watches.
Enjoy the time, my dear, don"t condemn me
Michael
Back to the Scrap-Yard
Ghazal, my Dear,
After dropping you at the Guesthouse today, I was quarreling once again with myself for having missed the opportunity to kiss you. It was silly, I know, in particular after I made this terrible observation at a scrap-yard for cars. There I found the remnants of a red Toyota Corolla, that had its upper part shaved away as if St.Michaels sword was used to convert into a cabriolet, and the chairs stained with blood. Obviously, a whole families life was extinguished in an terrible car accident, perhaps within tenth of a second.
Maybe at least once in life one should see how instantly all our long-term plans can literally end in a scrap-compactor and our patience while waiting for second chances in life becomes obsolete.
Therefore I so much enjoy the moments with you, although I always know in advance how terrible it will be later on, when I have to leave you.
Michael
............................................................................................
hi michael,
yes it is nice to be with you. but as friends. and we know that i will leave soon, to go back home.
about the kiss,i am greatful that you did not go so far because i appreciate your friendship very much.hope you understand.
good night and have a good week-end.
/ghazal
...........................................................................................
Hi Ghazal dear,
I very much appreciate your clear and firm statement, I think it is always best to be honest. I hope you considered my open, maybe shameless words in the last e-mail the same way and can tolerate them. The things are as they are, I have no clear idea how to handle it, no experience how to get alonge when emotional and professional relations intermingle. I very much admire that you deal with everything more wisely. For me it is a big help that you can live with the persian-cat blog (as long as it keeps your privacy intact) and that you have no problems communicating by e-mail with me.
What is most important right now, that your MSc project is not hampered, I think it even benefits from it. If you got a different feeling, please tell me.
Take Care, Sleep well
Michael
After dropping you at the Guesthouse today, I was quarreling once again with myself for having missed the opportunity to kiss you. It was silly, I know, in particular after I made this terrible observation at a scrap-yard for cars. There I found the remnants of a red Toyota Corolla, that had its upper part shaved away as if St.Michaels sword was used to convert into a cabriolet, and the chairs stained with blood. Obviously, a whole families life was extinguished in an terrible car accident, perhaps within tenth of a second.
Maybe at least once in life one should see how instantly all our long-term plans can literally end in a scrap-compactor and our patience while waiting for second chances in life becomes obsolete.
Therefore I so much enjoy the moments with you, although I always know in advance how terrible it will be later on, when I have to leave you.
Michael
............................................................................................
hi michael,
yes it is nice to be with you. but as friends. and we know that i will leave soon, to go back home.
about the kiss,i am greatful that you did not go so far because i appreciate your friendship very much.hope you understand.
good night and have a good week-end.
/ghazal
...........................................................................................
Hi Ghazal dear,
I very much appreciate your clear and firm statement, I think it is always best to be honest. I hope you considered my open, maybe shameless words in the last e-mail the same way and can tolerate them. The things are as they are, I have no clear idea how to handle it, no experience how to get alonge when emotional and professional relations intermingle. I very much admire that you deal with everything more wisely. For me it is a big help that you can live with the persian-cat blog (as long as it keeps your privacy intact) and that you have no problems communicating by e-mail with me.
What is most important right now, that your MSc project is not hampered, I think it even benefits from it. If you got a different feeling, please tell me.
Take Care, Sleep well
Michael
4.8.10
The Orphan Ghazal Receptor
Hi Ghazal, my Dear,
I hope everything went well today, that your family had a good flight and they like the flat and the neighbourhood and the fine car. You have been perhaps very busy organizing everything and enjoy to chat in your own language with your relatives.
Just would like to tell you, that Google had not managed to update their search results. The Persian-Cat blog went even higher on the list of hits after searching for your name. I have therefore replaced your name with the fictional "Azal". I know you are not pleased with this, my dear, but it will only be temporary, untill Google has "forgotten" that there is a relation between Persian-Cat and your family name (hope this will happen within the next 1-2 weeks). Then I"ll revert the changes. At the moment Google still finds the blog, but if somebody starts to read it seems as if Google associated your name and the blog by mistake.
It was not easy for me to replace your real name with this "Azal". I don"t mean the technical part, this was done just with a few mouse-clicks. But emotionally I did it with extreme unease.
I have no "receptor" for this abstract name "Azal", it does not induce memories of nice moments as it is the case with your real name. Therefore I hope, I can revert these changes as soon as possible.
I hope you have a nice and pleasant evening with your family and sleep well and dream something interesting.
Michael
I hope everything went well today, that your family had a good flight and they like the flat and the neighbourhood and the fine car. You have been perhaps very busy organizing everything and enjoy to chat in your own language with your relatives.
Just would like to tell you, that Google had not managed to update their search results. The Persian-Cat blog went even higher on the list of hits after searching for your name. I have therefore replaced your name with the fictional "Azal". I know you are not pleased with this, my dear, but it will only be temporary, untill Google has "forgotten" that there is a relation between Persian-Cat and your family name (hope this will happen within the next 1-2 weeks). Then I"ll revert the changes. At the moment Google still finds the blog, but if somebody starts to read it seems as if Google associated your name and the blog by mistake.
It was not easy for me to replace your real name with this "Azal". I don"t mean the technical part, this was done just with a few mouse-clicks. But emotionally I did it with extreme unease.
I have no "receptor" for this abstract name "Azal", it does not induce memories of nice moments as it is the case with your real name. Therefore I hope, I can revert these changes as soon as possible.
I hope you have a nice and pleasant evening with your family and sleep well and dream something interesting.
Michael
International Herald Tribune and Sauerkraut
hi michael!!
so sorry to bother you with my bike. wouldnt make it without your help. thank you.
i bought 3 sauerkraut!!! two for my family, and i will eat one today.
i have been thinking on what to write on my thesis in the introduction (separated from the aim), this is the subjects i thought about (and i have written a bit about each):
- thyroid in chernobyl
- thyroid morphology and the hormones
- the mice JF1 and FVB. and the mating and injection.
- gene mapping
- microsatellites
- QTL-analysis
you think this is good? is there something else..
do you want anything from sweden? or the airport?
have a good evening!
/ghazal
................................................................................................
Hi Ghazal, my Dear,
I just got your e-mail while I was contemplating about my own ignorance. I should not leave you so quickly today, I should not make the impression to come around only to screwing in the bike valves.
I should have stay for a bit longer to listen what you propose about the project outline.
In principle it is o.k. what you wrote. I would add something
-- about the specifity of thyroid cancer in exposed children (including developmental steps of this organ during adolescence).
-- general principles of inherited cancer susceptibility and specific cases of inherited susceptibility for acute or chronic radiation effects (like in XP-patients, ATM, NBCCS).
Relax, my dear, I will help you with everything. Don''''''''t worry,enjoy the days with your mom.
If you want to talk now, I"ll stay in the lab till about 10 p.m. (Tel. 31872628 , my mobile battery is down)
Thanks for asking if I like to have something from sweden or the airport. If you can pick-up an "International Herald Tribune" newspaper, this would be fine. Whenever you go to Sweden, bring me something personal, something I would have never thought of.
Take Care
Michael
...............................................................................................
Ghazal, my Dear,
I"ll go home now. Sorry, today I have no funny story to tell you. I hope you don"t mind and you are in good mood anyhow.
If you think I can do something for you (in addition to my duties as a supervisor), please write. But I"m afraid you are to shy.
Sleep well, don"t let obscure doubts bother you at night. You are mighty, you are bright, you are wunderful. Never forget this.
Take Care, my dear.
Michael
................................................................................................
hi michael,
where can they find this newspaper? i will tell them, but dont know if they will find it. have a good night!!
/ghazal
...............................................................................................
Ghazal my Dear,
Dont make to much effort, it is not worth it. Your family probably has a lot of luggage to carry, and they come to see you. Don"t let them search for the newspaper, its not so important. Sometimes the stewardess ask the passengers if somebody wants to read the "International Herald Tribune" on board, but really only if the stewardess offers them and delivers it to their seats. Please don"t ask your family to search for it on the airport.
I hope you all have a nice time and you can show your visitors around town a bit. Hope they got the same nice view from Munich as I got when you guided me around ;-}
Sleep well, in case I don"t hear anything from you the next days, I assume you are very bussy.
Take Care
Michael
PS: Are you serious about 2 packs of Sauerkraut for your family ???? Do you remember when you tried it first time in Unterschleissheim, when I gave you just some single slices to taste ? Maybe you also start with a small portion for your family. I assume they are not used to this type of very traditional food. Give them a chance to discover its taste slowly. Don"t force them to swallow a whole pack at once, same as you are doing it now.
so sorry to bother you with my bike. wouldnt make it without your help. thank you.
i bought 3 sauerkraut!!! two for my family, and i will eat one today.
i have been thinking on what to write on my thesis in the introduction (separated from the aim), this is the subjects i thought about (and i have written a bit about each):
- thyroid in chernobyl
- thyroid morphology and the hormones
- the mice JF1 and FVB. and the mating and injection.
- gene mapping
- microsatellites
- QTL-analysis
you think this is good? is there something else..
do you want anything from sweden? or the airport?
have a good evening!
/ghazal
................................................................................................
Hi Ghazal, my Dear,
I just got your e-mail while I was contemplating about my own ignorance. I should not leave you so quickly today, I should not make the impression to come around only to screwing in the bike valves.
I should have stay for a bit longer to listen what you propose about the project outline.
In principle it is o.k. what you wrote. I would add something
-- about the specifity of thyroid cancer in exposed children (including developmental steps of this organ during adolescence).
-- general principles of inherited cancer susceptibility and specific cases of inherited susceptibility for acute or chronic radiation effects (like in XP-patients, ATM, NBCCS).
Relax, my dear, I will help you with everything. Don''''''''t worry,enjoy the days with your mom.
If you want to talk now, I"ll stay in the lab till about 10 p.m. (Tel. 31872628 , my mobile battery is down)
Thanks for asking if I like to have something from sweden or the airport. If you can pick-up an "International Herald Tribune" newspaper, this would be fine. Whenever you go to Sweden, bring me something personal, something I would have never thought of.
Take Care
Michael
...............................................................................................
Ghazal, my Dear,
I"ll go home now. Sorry, today I have no funny story to tell you. I hope you don"t mind and you are in good mood anyhow.
If you think I can do something for you (in addition to my duties as a supervisor), please write. But I"m afraid you are to shy.
Sleep well, don"t let obscure doubts bother you at night. You are mighty, you are bright, you are wunderful. Never forget this.
Take Care, my dear.
Michael
................................................................................................
hi michael,
where can they find this newspaper? i will tell them, but dont know if they will find it. have a good night!!
/ghazal
...............................................................................................
Ghazal my Dear,
Dont make to much effort, it is not worth it. Your family probably has a lot of luggage to carry, and they come to see you. Don"t let them search for the newspaper, its not so important. Sometimes the stewardess ask the passengers if somebody wants to read the "International Herald Tribune" on board, but really only if the stewardess offers them and delivers it to their seats. Please don"t ask your family to search for it on the airport.
I hope you all have a nice time and you can show your visitors around town a bit. Hope they got the same nice view from Munich as I got when you guided me around ;-}
Sleep well, in case I don"t hear anything from you the next days, I assume you are very bussy.
Take Care
Michael
PS: Are you serious about 2 packs of Sauerkraut for your family ???? Do you remember when you tried it first time in Unterschleissheim, when I gave you just some single slices to taste ? Maybe you also start with a small portion for your family. I assume they are not used to this type of very traditional food. Give them a chance to discover its taste slowly. Don"t force them to swallow a whole pack at once, same as you are doing it now.
3.8.10
Button Front on Mens- and on Ladies Shirts
Ghazal,my Dear,
Are you allright ? I was waiting today to hear you proposing "Lets drive further, does not matter where, just to get away from the dark sky over Munich and find a place further away where the evening sun is shining." You are always very disciplined, Ghazal, you could be a bit more crazy, honestly. I think I was very crazy when I was your age (my poor parents, what they had to go through).
It was a pitty that today you did not even accepted some flowers that I was ready to pick from the field. I got the feeling you were not very happy today at all.
Just to bring you some humor befor you go to bed: I found a nice theory about the reason for the right- and left-handed button-ridge on mens versus ladies shirts: They claim it has the simple reason that men always dressed up themself (would be easier to do it on a right-sided buttons), whereas ladies had their servants helping them to dress and close the buttons on their shirts and dresses. For somebody who stands oposite you and has to do it, it would be easier if the buttons are on the oposite side. This theory is extensively described here:
O.k., I know you might reject this theory arguing that today no lady has servants to help her dress up any more. Well, Ghazal, don"t forget it might equally be relevant for the moment that a lady wants to take off her shirt. And here, servants or not, she can still expect to have some assistance from her partner.
Hope you don"t find my permanent desire for explanations slightly psychopathic and naughty. In this case, I have to apologize. But in general, there is not much else to feel guilty of. Therefore, sleep well, dream with passion, relax and wake up happy again.
Michael
........................................................................................
hi michael,
yes i am disciplined.. always been kind of. i am happy, just did not have energy to go out and pick some flowers. i think the ones we picked before were very nice:)
its an interesting theory this as well, i liked the other theory about the men with the sword.
have a good night and sorry for the bike. did not know it was just a tiny problem.
/ghazal
........................................................................................
Ghazal, my Dear,
I like so much reading some words of you. And it helps to understand. You are fascinating, and a hidden romantic, thats my conclusion when I read that you like the sword-theory. By the way, do you know that the mythological arch-angel Michael was equipped with a sword?
And that he was the ass-h..... who kicked adam and eve out of the garden eden ? Reading about him in Wikipedia one gets the feeling he was like the head of the police force, absolute inhuman.
I hope you don"t draw any conclusions from this, my Dear, Sleep well
Michael
Are you allright ? I was waiting today to hear you proposing "Lets drive further, does not matter where, just to get away from the dark sky over Munich and find a place further away where the evening sun is shining." You are always very disciplined, Ghazal, you could be a bit more crazy, honestly. I think I was very crazy when I was your age (my poor parents, what they had to go through).
It was a pitty that today you did not even accepted some flowers that I was ready to pick from the field. I got the feeling you were not very happy today at all.
Just to bring you some humor befor you go to bed: I found a nice theory about the reason for the right- and left-handed button-ridge on mens versus ladies shirts: They claim it has the simple reason that men always dressed up themself (would be easier to do it on a right-sided buttons), whereas ladies had their servants helping them to dress and close the buttons on their shirts and dresses. For somebody who stands oposite you and has to do it, it would be easier if the buttons are on the oposite side. This theory is extensively described here:
O.k., I know you might reject this theory arguing that today no lady has servants to help her dress up any more. Well, Ghazal, don"t forget it might equally be relevant for the moment that a lady wants to take off her shirt. And here, servants or not, she can still expect to have some assistance from her partner.
Hope you don"t find my permanent desire for explanations slightly psychopathic and naughty. In this case, I have to apologize. But in general, there is not much else to feel guilty of. Therefore, sleep well, dream with passion, relax and wake up happy again.
Michael
........................................................................................
hi michael,
yes i am disciplined.. always been kind of. i am happy, just did not have energy to go out and pick some flowers. i think the ones we picked before were very nice:)
its an interesting theory this as well, i liked the other theory about the men with the sword.
have a good night and sorry for the bike. did not know it was just a tiny problem.
/ghazal
........................................................................................
Ghazal, my Dear,
I like so much reading some words of you. And it helps to understand. You are fascinating, and a hidden romantic, thats my conclusion when I read that you like the sword-theory. By the way, do you know that the mythological arch-angel Michael was equipped with a sword?
And that he was the ass-h..... who kicked adam and eve out of the garden eden ? Reading about him in Wikipedia one gets the feeling he was like the head of the police force, absolute inhuman.
I hope you don"t draw any conclusions from this, my Dear, Sleep well
Michael
2.8.10
Google finds us, even if we try to hide !!!
Ghazal my Dear,
Did you had a nice Sunday. Hope you discovered some exciting new subjects from the books or papers you read. I would be very keen to share what you read. I like very much to learn from you about some new developments, like recently about the UV-induced melanin regulation. (Today in the mountains I tried my best to protect from the strong UV in high altitude waering a huge hat and sun glasses).
Write me that you are happy, this will make me happy as well.
Enjoy the evening, the night and your dreams.
Michael
........................................................................................
hi michael,
did not discover a lot of new information. just tried to write down some about chernobyl for my thesis. im not quite sure about what i should have in the thesis. i put up some subjects to write about, but dont know if it is enough or maybe not necessary.
but UV is good also, to get vitamin D or something. so everything is good in a normal amount. but its best to protect yes.
have a good night and see you tomorrow.
ooh, for the homepage, persian-cat. could you make it private? because if you search for my name on google you will find it on the first page.
thank you
/ghazal
.......................................................................................
Hi Ghazal, my Dear,
Nice to hear from you.
I"ll give you some stuff about the motivation for the Thyroid Project tomorrow, so you might use it as "raw material".
I"m very sorry with the blog having risked your privacy. I tried to avoid any hint for outsiders to identify you. I simply forgot to remove your family name from one entry. I removed it now right away. Sorry again for this. I will check tomorrow if Google still finds the blog by searching your name.
Sleep well, don"t worry my Dear.
Michael
Did you had a nice Sunday. Hope you discovered some exciting new subjects from the books or papers you read. I would be very keen to share what you read. I like very much to learn from you about some new developments, like recently about the UV-induced melanin regulation. (Today in the mountains I tried my best to protect from the strong UV in high altitude waering a huge hat and sun glasses).
Write me that you are happy, this will make me happy as well.
Enjoy the evening, the night and your dreams.
Michael
........................................................................................
hi michael,
did not discover a lot of new information. just tried to write down some about chernobyl for my thesis. im not quite sure about what i should have in the thesis. i put up some subjects to write about, but dont know if it is enough or maybe not necessary.
but UV is good also, to get vitamin D or something. so everything is good in a normal amount. but its best to protect yes.
have a good night and see you tomorrow.
ooh, for the homepage, persian-cat. could you make it private? because if you search for my name on google you will find it on the first page.
thank you
/ghazal
.......................................................................................
Hi Ghazal, my Dear,
Nice to hear from you.
I"ll give you some stuff about the motivation for the Thyroid Project tomorrow, so you might use it as "raw material".
I"m very sorry with the blog having risked your privacy. I tried to avoid any hint for outsiders to identify you. I simply forgot to remove your family name from one entry. I removed it now right away. Sorry again for this. I will check tomorrow if Google still finds the blog by searching your name.
Sleep well, don"t worry my Dear.
Michael
1.8.10
Tell me you are happy !
Ghazal, my Dear,
Are you o.k. ? I haven"t heard anything from you since Friday. Please write some words, so I don"t have to worry. I understand that "... you grown up and can take care of yourself:)" , but anyhow I just like to hear you are happy.
Take Care
Michael .
.........................................................................................................
hi michael,
yes i am fine! hope that you are having a good time with your sister.
take care
/ghazal
.........................................................................................................
Hi Ghazal,
Relieved to read you are allright. We will make a short trip to the mountains today. In case you want to join, give me a call. We will leave at around 11 a.m.
Anyway, enjoy the day, my dear.
Michael
.........................................................................................................
hi michael,
sounds good. hope you will have a nice time there in the mounatins. i will try to study. but thanx for asking.
see you tomorrow.
/ghazal
Are you o.k. ? I haven"t heard anything from you since Friday. Please write some words, so I don"t have to worry. I understand that "... you grown up and can take care of yourself:)" , but anyhow I just like to hear you are happy.
Take Care
Michael .
.........................................................................................................
hi michael,
yes i am fine! hope that you are having a good time with your sister.
take care
/ghazal
.........................................................................................................
Hi Ghazal,
Relieved to read you are allright. We will make a short trip to the mountains today. In case you want to join, give me a call. We will leave at around 11 a.m.
Anyway, enjoy the day, my dear.
Michael
.........................................................................................................
hi michael,
sounds good. hope you will have a nice time there in the mounatins. i will try to study. but thanx for asking.
see you tomorrow.
/ghazal
Who is supervising whom ?
Hi Ghazal my Dear,
Have a nice weekend, relax. If you need something, write a message or call. I hope you understoud that my remark from yesterday about "supervising your good behaviour in the public" was ment to be a joke.
Later on, when we were sitting on the S-Bahn platform it appeared to me that you are in fact much more responsible and experienced in everything you do than I am. In fact, I feel a sort of safer and protected when you are there. Strange it is, I can"t explaine.
I think of you
Take Care
Michael .
...............................................................................................
Ghazal, my Dear,
Hope you had a nice sunny day today. In the morning Prof. T. contact me requesting to invite all current M.Sc. and former M.Sc. students to meet a lady from Fridericus-Foundation to say thank-you for her support. I could only give him O"s mobile-number. I assume you are not too disappointed that you missed this "unique opportunity" talking about the course on a Saturday morning.
Are you at home now ? Did you watch the Insomnia-movie ?
Maybe the sun made you tired. In this case, sleep well, relax, take a night flight in your dreams (or a night drive, if you prefer).
Michael
Have a nice weekend, relax. If you need something, write a message or call. I hope you understoud that my remark from yesterday about "supervising your good behaviour in the public" was ment to be a joke.
Later on, when we were sitting on the S-Bahn platform it appeared to me that you are in fact much more responsible and experienced in everything you do than I am. In fact, I feel a sort of safer and protected when you are there. Strange it is, I can"t explaine.
I think of you
Take Care
Michael .
...............................................................................................
Ghazal, my Dear,
Hope you had a nice sunny day today. In the morning Prof. T. contact me requesting to invite all current M.Sc. and former M.Sc. students to meet a lady from Fridericus-Foundation to say thank-you for her support. I could only give him O"s mobile-number. I assume you are not too disappointed that you missed this "unique opportunity" talking about the course on a Saturday morning.
Are you at home now ? Did you watch the Insomnia-movie ?
Maybe the sun made you tired. In this case, sleep well, relax, take a night flight in your dreams (or a night drive, if you prefer).
Michael
Subscribe to:
Posts (Atom)